First human corneas have been 3D printed by scientists at Newcastle University (Video)

human corneas

First human corneas have been 3D printed by scientists at Newcastle University

It means the technique could be used in the future to ensure an unlimited supply of corneas. As the outermost layer of the human eye, the cornea has an important role in focusing vision.

Yet there is a significant shortage of corneas available to transplant, with 10 million people worldwide requiring surgery to prevent corneal blindness as a result of diseases such as trachoma, an infectious eye disorder.

In addition, almost 5 million people suffer total blindness due to corneal scarring caused by burns, lacerations, abrasion or disease. Continue reading “First human corneas have been 3D printed by scientists at Newcastle University (Video)”

Carnegie Mellon University researchers develop low-cost open-source 3D bioprinter (Video)

3D bioprinter

Researchers at Carnegie Mellon University have developed a low-cost 3D bioprinter by modifying a standard desktop 3-D printer, and they have released the breakthrough designs as open source so that anyone can build their own system. The researchers—Materials Science and Engineering (MSE) and Biomedical Engineering (BME) Associate Professor Adam Feinberg, BME postdoctoral fellow TJ Hinton, and Kira Pusch, a recent graduate of the MSE undergraduate program—recently published a paper in the journal HardwareX that contains complete instructions for printing and installing the syringe-based, large volume extruder (LVE) to modify any typical, commercial plastic printer.

“What we’ve created,” says Pusch, “is a large volume syringe pump extruder that works with almost any open source fused deposition modeling (FDM) printer. This means that it’s an inexpensive and relatively easy adaptation for people who use 3-D printers.” Continue reading “Carnegie Mellon University researchers develop low-cost open-source 3D bioprinter (Video)”

3D printing and programming genetically engineered bacteria

genetically engineered bacteria

Wearable tech is the name given to smart electronic devices that can be worn or implanted in the body. An enticing opportunity for innovative tech developers in sports, health, fashion and entertainment, 3D printing is revealing new possibilities for wearable tech such as electronic second skins, and smart fabrics.

In the latest research from Massachusetts Institute of Technology (MIT), a team has developed a “living” 3D printer bio-ink that’s not only smart but could change the way we think about technology altogether. Harnessing natural reactions of bacteria, responsive devices made using this smart ink represent the basic build blocks of electricity-free wearable tech.

Made by members of the same team that made the soft-robotic, fish-catching glove, this 3D printable bio-ink adds to an extensive portfolio of smart materials in development at MIT. Continue reading “3D printing and programming genetically engineered bacteria”

Multimaterial and Multiscale Biofabrication of 3D in vitro models of complex tissues – Presented by Giovanni Vozzi, University of Pisa

Giovanni Vozzi

Multimaterial and Multiscale Biofabrication of 3D in vitro models of complex tissues – Presented by Giovanni Vozzi, University of Pisa, at the 3D Medical Conference, which will take place on 30-31 January 2018 at MECC Maastricht, The Netherlands. Read the interview

A biological tissue is a composite material with “bottom-up” hierarchical structure that is closely related to its heterogeneous function. The extracellular matrix modulates biochemical and biophysical signalling, and its rigidity is an important microenvironmental parameter that regulates the spatiotemporal dynamics of intercellular signalling. For this reason, many studies are focused on fabricating scaffolds processed at multiple scales with structural and mechanical properties that are optimal for eliciting specific response or mimic those found naturally. These scaffolds have to present large surface areas that have appropriate topology and biochemical cues (e.g, ligands) at the nanoscale for tissue adhesion, while also exhibiting integral porosity to allow for the exchange of molecules that maintain cellular function.

In this talk, the use of a multiscale and multimaterial process will be presented to develop 3D in vitro model that can mimic the 3D complexity of natural tissue. These novel 3D in vitro models can be used for the study of physio-pathological condition and for the analysis of effects on cell activities of different biomolecule and/or drugs. Continue reading “Multimaterial and Multiscale Biofabrication of 3D in vitro models of complex tissues – Presented by Giovanni Vozzi, University of Pisa”

GE Healthcare opens first 3D Printing lab

GE Healthcare

GE Healthcare opens first 3D Printing lab

GE Healthcare has opened its first 3D printing lab, called the Innovative Design and Advanced Manufacturing Technology Center for Europe, in Uppsala, Sweden. The center will use technologies including 3D printing and robotics to speed up the launch of new innovative products for the healthcare industry.

The center combines advanced manufacturing technology such as metal and polymer printers and collaborative robots, or “cobots”, with traditional machining equipment. A key in realizing the advantages of 3D printing is ensuring the technology is considered at the start of the innovation process with Research and Design teams working with advanced manufacturing engineers and in collaboration with customers. The new center in Uppsala will ensure additive expertise is available from the start of product design. Teams will design, test and produce 3D-printed parts for GE Healthcare products and prepare for final transfer to manufacturing. Continue reading “GE Healthcare opens first 3D Printing lab”

New method to 3D Print laboratory-grown cells to form living structures, developed by Oxford researchers

3D Print laboratory-grown cells

New method to 3D Print laboratory-grown cells to form living structures, developed by Oxford researchers

The approach could revolutionise regenerative medicine, enabling the production of complex tissues and cartilage that would potentially support, repair or augment diseased and damaged areas of the body.

Printing high-resolution living tissues is hard to do, as the cells often move within printed structures and can collapse on themselves. But, led by Professor Hagan Bayley, Professor of Chemical Biology in Oxford’s Department of Chemistry, the team devised a way to produce tissues in self-contained cells that support the structures to keep their shape.

The cells were contained within protective nanolitre droplets wrapped in a lipid coating that could be assembled, layer-by-layer, into living structures. Producing printed tissues in this way improves the survival rate of the individual cells, and allowed the team to improve on current techniques by building each tissue one drop at a time to a more favourable resolution. Continue reading “New method to 3D Print laboratory-grown cells to form living structures, developed by Oxford researchers”

Brave new world of 3D printed organs now includes implanted ovary structures (Video)

3D printed organs

The brave new world of 3D printed organs now includes implanted ovary structures that, true to their design, actually ovulate, according to a study by Northwestern University Feinberg School of Medicine and McCormick School of Engineering.

By removing a female mouse’s ovary and replacing it with a bioprosthetic ovary, the mouse was able to not only ovulate but also give birth to healthy pups. The moms were even able to nurse their young.

The bioprosthetic ovaries are constructed of 3-D printed scaffolds that house immature eggs, and have been successful in boosting hormone production and restoring fertility in mice, which was the ultimate goal of the research. Continue reading “Brave new world of 3D printed organs now includes implanted ovary structures (Video)”

Is Herston Biofabrication Institute creating the hospital of the future?

Herston Biofabrication Institute

Is Herston Biofabrication Institute creating the hospital of the future? Advances in biofabrication research led by the Herston Biofabrication Institute will transform the way we provide health care by producing innovative personalized and automated treatments.

The Herston Biofabrication Institute is a partnership between Metro North Hospital and Health Service, and QUT.

Launching in 2017, the Herston Biofabrication Institute will advance knowledge and technology in 3D scanning, modelling and printing of bone, cartilage and other human tissue to repair tissue that is lost or damaged. Continue reading “Is Herston Biofabrication Institute creating the hospital of the future?”

Moroni Lab – Largest European 3D bioprinting program launched by Maastricht University, Brightlands Materials Center

3D bioprinting program

Moroni Lab – Largest European 3D bioprinting program launched by Maastricht University, Brightlands Materials Center. It looks like Maastricht University is rapidly becoming one of Europe’s key centers for medical 3D printing efforts. Just this month, they spearheaded the new €4.6 million PRosPERoS project for 3D printed joint implant development, while researchers from Maastricht’s Moroni lab pioneered 3D bioprinted scaffolds that control stem cell differentiation. Continue reading “Moroni Lab – Largest European 3D bioprinting program launched by Maastricht University, Brightlands Materials Center”