Custom 3D-printed organic implants project funded with CHF 12 million

organic

Researchers at the University of Basel have a vision: an individually configurable robot that will revolutionize surgical procedures and provide numerous benefits for patients. They have already taken the first steps in this direction. To further implement their vision, the Werner Siemens Foundation is now extending its funding for the “Miracle” project by CHF 12 million to a total of CHF 27 million.

Continue reading “Custom 3D-printed organic implants project funded with CHF 12 million”

Merck and EOS jointly develop powder based 3D Printer for printing tablets

tablets

Large-scale tablet production as we know it today was invented in the late 19th century. Although the machinery has, of course, become more modern, the manufacturing process has hardly changed and is still based on the compression of powders and granules.

This traditional tablet manufacturing process is very efficient for large-scale production. Yet, when active pharmaceutical ingredient (API) dosages need to be adapted – as it is the case for clinical studies or for any tablet batch production in smaller volumes – the process is both extremely time-consuming and expensive.

Merck together with EOS is currently developing a GMP-qualified solution that uses additive manufacturing (commonly known as 3D printing) technology combined with powder formulation. Laser sintering technology will simplify tablet production tremendously, leading to significant cost and time savings in clinical development.

PRODUCTION OF TABLETS HAS NEVER BEEN SIMPLER, FASTER AND CHEAPER

Tablet manufacturing using additive manufacturing will be as easy as “mixing, printing, done”. The API is mixed with excipients as a powder. A laser then fuses the mixture in a powder bed into tablets layer by layer. The tablets are then coated, and it’s all done!

In addition, 3D printing allows for API formulation to be scalable while avoiding costly reformulations throughout the entire pharmaceutical development and commercial production processes.  

This novel approach is being pursued at the Merck Innovation Center, which brings ideas, knowledge and people together to create new viable businesses beyond the company’s current scope. The innovation project can benefit greatly from the long-standing formulation expertise of our Healthcare business sector as well as the experience of our Life Science business with excipients. In addition, we are partnering with EOS, the world’s leading technology supplier in the field of industrial 3D printing of metals and polymers, on this project.

The goal is to establish, in a first step, a Contract Development and Manufacturing Organization offering tablet formulation development and production for clinical trials.

In addition to making tablet manufacturing simpler and reducing time and costs, we envision making it possible to mass produce tablets flexibly and sustainably in line with patient needs. Tablet production could be tailored locally to meet specific market requirements, for example. Or imagine how it could benefit children or elderly people by providing them with tablets in special shapes and colors so that they can easily recognize their medications.

The conference of 3D Medical Printing Conference covers the development of 3D Pharma Printing.

Read more about the Merck / EOS project on the website.

Research on the benefits of 3D printing in Dutch trauma hospital (Video)

3D printing

3D printing is seeing increasingly widespread adoption in the medical field, with numerous examples of applications that help surgeons accurately plan cosmetic surgery. Now, the potential of 3D printing is being examined by hospitals treating patients who are fighting for their life.

The ETZ (Elisabeth-TweeSteden Ziekenhuis) is one of the eleven trauma centers in the Netherlands. As the only center in the country with trauma surgeons on location 24 hours a day, it serves as the main location for emergency patients in North Brabant. 3D printing has already been used to visualize bone fractures, but pioneering researchers believe it can also be used to help treat trauma patients.

Mike Bemelman, MD, trauma surgeon at the ETZ, had already seen the potential of 3D printing back in 2016. Together with Lars Brouwers, MD, PhD-candidate, and Koen Lansink, MD, trauma surgeon, they have started conducting research into the benefits and effectiveness of 3D printing, compared to traditional and other new technologies. Their idea is to 3D print scanned bone fractures in order to give both surgeons and patients a clear understanding of each situation, before operating. Continue reading “Research on the benefits of 3D printing in Dutch trauma hospital (Video)”

ETH researchers develop silicone heart that beats almost like a human heart (Video)

silicone heart

ETH researchers from the Functional Materials Laboratory have developed a silicone heart that beats almost like a human heart. In collaboration with colleagues from the Product Development Group Zurich, they have tested how well it works.

It looks like a real heart. And this is the goal of the first entirely soft artificial heart: to mimic its natural model as closely as possible. The silicone heart has been developed by Nicholas Cohrs, a doctoral student in the group led by Wendelin Stark, Professor of Functional Materials Engineering at ETH Zurich. The reasoning why nature should be used as a model is clear. Currently used blood pumps have many disadvantages: their mechanical parts are susceptible to complications while the patient lacks a physiological pulse, which is assumed to have some consequences for the patient. Continue reading “ETH researchers develop silicone heart that beats almost like a human heart (Video)”

GE Healthcare opens first 3D Printing lab

GE Healthcare

GE Healthcare opens first 3D Printing lab

GE Healthcare has opened its first 3D printing lab, called the Innovative Design and Advanced Manufacturing Technology Center for Europe, in Uppsala, Sweden. The center will use technologies including 3D printing and robotics to speed up the launch of new innovative products for the healthcare industry.

The center combines advanced manufacturing technology such as metal and polymer printers and collaborative robots, or “cobots”, with traditional machining equipment. A key in realizing the advantages of 3D printing is ensuring the technology is considered at the start of the innovation process with Research and Design teams working with advanced manufacturing engineers and in collaboration with customers. The new center in Uppsala will ensure additive expertise is available from the start of product design. Teams will design, test and produce 3D-printed parts for GE Healthcare products and prepare for final transfer to manufacturing. Continue reading “GE Healthcare opens first 3D Printing lab”

New bioprinting technology to be developed by UMC Utrecht, regenHU (VIDEO)

bioprinting

New bioprinting technology to be developed by UMC Utrecht, regenHU. Partnering experts in 3D bioprinting with experts in biomanufacturing has resulted in the first melt electrospinning device that incorporates the use of bio-inks. Housed at the Utrecht Biofabrication Facility, this combination of techniques may lead to improved and more accurate 3D bioprinting for therapeutic use. The Utrecht Biofabrication Facility was established with support of Utrecht University and the UMC Utrecht in 2013. Continue reading “New bioprinting technology to be developed by UMC Utrecht, regenHU (VIDEO)”

Utrecht3DMedical – 3D Bioprinting Lab in Utrecht

The city of Utrecht in Netherland is already famous for the outstanding achievements made by the tissue factory subordinated to the University Medical Center Utrecht to a great extent. This tissue factory has recently accomplished the 3D bioprinted rabbit shoulder implantation experiment. Now, this city is attracting more biologic printing institutions. With the cooperation of the University Medical Center Utrecht, Hogeschool Utrecht and ProtoSpace Fund, a new bioprinting lab Utrecht3DMedical is established. Continue reading “Utrecht3DMedical – 3D Bioprinting Lab in Utrecht”

Research Proves Superiority of 3D Bioprinted Human Liver Tissues in Assessing Drug-Induced Toxicity

Organovo Holdings, Inc., a three-dimensional biology company focused on delivering scientific and medical breakthroughs using its 3D bioprinting technology, today announced a publication in the scientific journal, PLOS One, which demonstrates the superiority of Organovo’s 3D bioprinted human liver tissues to effectively model drug-induced liver injury and distinguish between highly-related compounds with different toxicity profiles.  Continue reading “Research Proves Superiority of 3D Bioprinted Human Liver Tissues in Assessing Drug-Induced Toxicity”

3D printed silk ‘micro-rockets’ could deliver medicines through your body (Video)

3D printed silk ‘micro-rockets’ could deliver medicines through your body

Sheffield engineers make major breakthrough in developing silk ‘micro-rockets’ that can be used safely in biological environments.

By using an innovative 3D inkjet printing method, researchers from Chemical and Biological Engineering at the University of Sheffield have taken the biggest step yet in producing microscopic silk swimming devices that are biodegradable and harmless to a biological system. Continue reading “3D printed silk ‘micro-rockets’ could deliver medicines through your body (Video)”