by Carlos Mota, MERLN – Institute for Technology-Inspired Regenerative Medicine
End-stage renal disease (ESRD) affect 10% of the world’s population. Temporary therapies such as dialysis and organ transplantation are deemed insufficient for ESRD patient treatment. Furthermore, due to donor organ shortage multiple patients die while waiting for a suitable organ. Alternative therapies are of outmost importance to circumvent these limitations, but suitable approached to investigate renal disease and regeneration are limited are still largely dependent on animal models. In vitro models with relevant physiologic mimicry and function are necessary for the development of alternative therapies and to unravel new treatment possibilities.
I have built up extensive experience in communication & marketing in agencies. However, at 3D ADEPT Media, I have been able grow exponentially and to find something more valuable: authentic values and a common mission: the one to support companies in building the world of tomorrow through innovations. If you are looking for a trade press that is committed to tracking and analyzing the good and the areas for improvement in all sectors related to additive manufacturing, then stay tuned to 3D ADEPT Media.
Prosperos is a 4 year, 4.5M€ project, focussed on developing the next generation of 3D printed implants. The project is funded by the Interreg V Flanders – the Netherlands program. A lot was learned about the technology, the application, and hurdles towards introduction of these implants into the clinic. During this presentation we would like to share the (preliminary) results and the most important lessons learned.
The industrial uptake of Additive Manufacturing and 3D printing processes is growing rapidly but is being hampered by the lack of breadth of materials usable in such systems. Identifying, and then optimisating formulations for 3D printing is time consuming, and generally involves many tedious steps each of which require lengthy analysis.
Smart hydrogels reversibly change their properties when exposed to an external driven force as pH or temperature variation (1). Methylcellulose (MC) is a polysaccharide derived from cellulose and when dissolved in aqueous solvents it forms reverse thermo-responsive smart hydrogels that undergo a sol-gel transition when heated (2).
At the same time, another smart material is represented by gelatin that needs to be crosslinked for biomedical applications. Crosslinked gelatin bulk scaffolds, 3D printed structures and microspheres can be obtained by tuning its crosslinking kinetic, innovatively without the need of post-curing or external treatments to stabilize the crosslinked printed hydrogel structure (3).
By Prasad Shastri, Professor of Biofunctional Macromolecular Chemistry & Bioss Professor of Cell Signalling Environments / Director, Institute for Macromolecular Chemistry at University of Freiburg
3D-Bioprinting holds much promise in advancing medicine as tool to replicate cellular complexity of tissue environment ex vivo for drug screening and as a means of engineering well-defined functional tissue units for transplantation. In regards to the latter, 3D-bioprinting offers a critical link between principles of tissue engineering and patient-specific delivery of healthcare.
Simon Vanooteghem, 3D Printing in Healthcare – Business Development, Materialise
& Maaike Koenrades, Project Lead 3D Lab & Technical Physician, Medisch Spectrum Twente
Over the past 20 years, 3D Printing has emerged as a disruptive technology in the healthcare field — it’s been used to create custom devices and instruments, plan complex medical procedures, and to better train future medical professionals. As the accessibility to the technology increases, hospitals are beginning to adopt 3D printing programs within their own institutions, aiming to reduce lead times for 3D-printed models and to build knowledge internally.