Disruptive Multi Material 3D Technology

Rene van der Meer

by Rene van der Meer, Lake3D

The start-up Lake3D wants to develop the first 3D Dental printer based on Multi Material 3D inkjet. It uses printheads suited for high temperatures and high viscous materials that make it possible to jet class II medically certified materials that are already being used in traditional 3D (SLA) printers. Combining different materials makes it possible to print objects with the right colour, transparency and mechanical characteristics. This might bring a revolution in 3D printing as colour did in television.

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Printing medical devices under the MDR: changed world?

Jan-Paul van Loon

by Jan-Paul van Loon, Qserve Consultancy BV

On May 26, 2020, the new Medical Device Regulation (MDR) will come into force, and Hospitals and Industry are getting increasingly nervous as this date approaches. Although the MDR is not particularly stricter than the current Medical Device Directive (MDD) for custom-made device manufacturers, there are differences, as for example the necessity of a “Person Responsible for Regulatory Compliance”, and more extensive Post-Market Surveillance requirements.

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Digital Drug Manufacturing – towards truly personalized drug delivery

Anton Aulbers

by Anton Aulbers, TNO

One of the challenges of the pharma industry is the need for faster development and production of drug dosage forms for ever smaller target groups. TNO has built up a solid position and reputation in the field of 3D printing for the food industry.

Making use of this know-how base TNO is now together with partners, initiating innovations, in the pharma value chain, to unlock the potential of 3D Pharma printing as an enabling technology for cost effective small scale drug product manufacturing, dose personalization, multi-drug combinations and tailored release profiles.

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Using digital twins to design 3D printed implants for skeletal tissue engineering

Liesbet Geris

by Liesbet Geris, University of Liege

One of the major challenges in tissue engineering and an essential step towards successful clinical applications is the translation of biological knowledge on complex cell and tissue behavior into predictive and robust engineering processes. Computational modelling can contribute to this, among others because it allows to study the biological complexity in a more quantitative way. Computational tools can help in quantifying and optimizing micro-environmental signals to which cells and tissues are exposed and in understanding and predicting the biological response under different conditions.

A wide variety of model systems has been presented in the context of tissue engineering ranging from empirical models (data-driven) over gene network models to mechanistic models (hypothesis-based), targeting processes at the intracellular over the cellular up to the tissue level. Each model system has its own benefits and limitations which delineate the context in which it can be used. Whereas mechanistic models are used as in silico tools to design new therapeutic strategies and experiments, empirical models are used to identify, in large data sets, those in vitro parameters (biological, biomaterial, environmental) that are critical for the in vivo outcome.

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What if every scientist had an easy way to print and pattern cells

Ricky Solorzano

by Ricky Solorzano, CEO, Allevi

In an era where bioprinting continues to hold promise sometimes its hard to understand why and how are they useful. What key applications will allow me to take my research to the next level and stay on the cutting edge. Come and listen to the key ways bioprinting is being most commonly used by researchers around the world.

program: https://3dmedicalconference.com/program/

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Boosting bone regeneration: Additive manufacturing of continuous gradient scaffolds using functional composite materials

Maria Camara Torres

by Maria Camara Torres, MERLN Institute for Technology Inspired Regenerative Medicine

Bone fractures, infection related debridement, or tumor resections can lead to large or non-union bone defects, where the normal process of bone regeneration is interrupted and prevent bone self-healing ability. By using scaffolds, tissue engineering aims at providing structural and biological support to regenerate bone. While additive manufacturing (AM) enables to fabricate patient specific 3D scaffolds with optimal mechanical properties and architecture, there is still a need of technologies and materials that allow to fabricate functional scaffolds for regenerating tissues in their complexity.

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In-situ process monitoring during the Selective Laser Melted Ti-6Al-4V porous biomaterials

denis dowling

by Professor Denis Dowling, Director, I-Form Advanced Manufacturing Research Centre, University College Dublin

Selective Laser Melting (SLM) allows for the creation of complex cellular structures, that possess favourable biological properties, these structures are known as porous biomaterials.

This presentation will provide an overview of the printing of cellular Ti-6Al-4V structures, using a production scale SLM system (Renishaw 500M).

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3D-printing of photo-crosslinkable polymers for tissue engineering purposes

Sandra Van Vlierberghe

by Sandra Van Vlierberghe, Professor (BOF-ZAP), Ghent University

Biofabrication is a specific area within the field of tissue engineering which takes advantage of rapid manufacturing (RM) techniques to generate 3D structures which mimic the natural extracellular matrix (ECM). A popular material in this respect is gelatin, as it is a cost-effective collagen derivative, which is the major constituent of the natural ECM. The material is characterized by an upper critical solution temperature making the material soluble at physiological conditions. To tackle this problem, the present work focusses on different gelatin functionalization strategies which enable covalent stabilization of 3D gelatin structures [1, 2].

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