Multimaterial and Multiscale Biofabrication of 3D in vitro models of complex tissues – Presented by Giovanni Vozzi, University of Pisa

Giovanni Vozzi

Multimaterial and Multiscale Biofabrication of 3D in vitro models of complex tissues – Presented by Giovanni Vozzi, University of Pisa, at the 3D Medical Conference, which will take place on 30-31 January 2018 at MECC Maastricht, The Netherlands. Read the interview

A biological tissue is a composite material with “bottom-up” hierarchical structure that is closely related to its heterogeneous function. The extracellular matrix modulates biochemical and biophysical signalling, and its rigidity is an important microenvironmental parameter that regulates the spatiotemporal dynamics of intercellular signalling. For this reason, many studies are focused on fabricating scaffolds processed at multiple scales with structural and mechanical properties that are optimal for eliciting specific response or mimic those found naturally. These scaffolds have to present large surface areas that have appropriate topology and biochemical cues (e.g, ligands) at the nanoscale for tissue adhesion, while also exhibiting integral porosity to allow for the exchange of molecules that maintain cellular function.

In this talk, the use of a multiscale and multimaterial process will be presented to develop 3D in vitro model that can mimic the 3D complexity of natural tissue. These novel 3D in vitro models can be used for the study of physio-pathological condition and for the analysis of effects on cell activities of different biomolecule and/or drugs. Continue reading “Multimaterial and Multiscale Biofabrication of 3D in vitro models of complex tissues – Presented by Giovanni Vozzi, University of Pisa”

Research Proves Superiority of 3D Bioprinted Human Liver Tissues in Assessing Drug-Induced Toxicity

Organovo Holdings, Inc., a three-dimensional biology company focused on delivering scientific and medical breakthroughs using its 3D bioprinting technology, today announced a publication in the scientific journal, PLOS One, which demonstrates the superiority of Organovo’s 3D bioprinted human liver tissues to effectively model drug-induced liver injury and distinguish between highly-related compounds with different toxicity profiles.  Continue reading “Research Proves Superiority of 3D Bioprinted Human Liver Tissues in Assessing Drug-Induced Toxicity”

First successful printing of cardiac and vascular structures in zero gravity (Video)

A trio of high-tech companies have teamed up to develop a space hardened 3D bioprinter capable of manufacturing human organs and tissues in orbit. A June 14 test of the consortium’s prototype resulted in the first successful printing of cardiac and vascular structures in zero gravity with adult human stem cells. The experiment was performed 30,000 feet over the Gulf of Mexico aboard a Zero Gravity Corporation aircraft capable of repeatedly producing several seconds of sustained microgravity. Continue reading “First successful printing of cardiac and vascular structures in zero gravity (Video)”

Harvard Researchers Reveal New Method for 3D Bioprinting Thick Vascularized Tissue (Video)

A team at the Wyss Institute for Biologically Inspired Engineering at Harvard University and the Harvard John A. Paulson School for Engineering and Applied Sciences (SEAS) has invented a method for 3D bioprinting thick vascularized tissue constructs composed of human stem cells, extracellular matrix, and circulatory channels lined with endothelial blood vessel cells. The resulting network of vasculature contained within these deep tissues enables fluids, nutrients and cell growth factors to be controllably perfused uniformly throughout the tissue. The advance is reported March 7 in the journal Proceedings of the National Academy of Sciences. Continue reading “Harvard Researchers Reveal New Method for 3D Bioprinting Thick Vascularized Tissue (Video)”

French Poietis raises €2.5mn financing to develop technology that will bring to market its first bioprinted tissues

Poietis, French leader of Bioprinting, continues its growth by closing a first round of financing of €2.5 million including a fundraising record of nearly €1 million via the crowdfunding platform WiSEED. The funds raised will be used to industrialize Poietis Laser-Assisted Bioprinting technology and bring to market its first bioprinted tissues. Continue reading “French Poietis raises €2.5mn financing to develop technology that will bring to market its first bioprinted tissues”

MIT’s Biologic program attempts to program living organism and create organically reactive material (Video)

bioLogic is growing living actuators and synthesizing responsive bio-skin in the era where bio is the new interface. We are Imagining a world where actuators and sensors can be grown rather than manufactured, being derived from nature as opposed to engineered in factories. Continue reading “MIT’s Biologic program attempts to program living organism and create organically reactive material (Video)”

“REGEMAT 3D bioprinting for cartilage regeneration and much more”, Presented by Jose Manuel Baena, REGEMAT 3D

Tissue regeneration (TR) is currently one of the most challenging biotechnology unsolved problems. Tissue engineering (TE) is a multidisciplinary science that aims at solving the problems of TR. TE could solve pathologies and improve the quality of life of billions of people around the world suffering from tissue damages.

New advances in stem cell (SC) research for the regeneration of tissue injuries have opened a new promising research field. However, research carried out nowadays with two-dimensional (2D) cell cultures do not provide the expected results, as 2D cultures do not mimic the 3D structure of a living tissue. Continue reading ““REGEMAT 3D bioprinting for cartilage regeneration and much more”, Presented by Jose Manuel Baena, REGEMAT 3D”

Organovo Patents Methodology for Producing Kidney Cells from Induced Pluripotent Stem Cells

UniQuest, the main technology transfer and commercialisation company of The University of Queensland (UQ), has signed an exclusive worldwide licensing agreement with Organovo Holdings, Inc. (NYSE MKT:ONVO), a three-dimensional biology company focused on delivering scientific and medical breakthroughs using its 3D bioprinting technology, to patent applications relating to methodology for producing kidney cells from induced pluripotent stem cells (iPSCs).

Professor Melissa Little and her team at UQ’s Institute for Molecular Bioscience developed a method of growing kidney tissue from iPSCs for potential use in drug screening, disease modelling and cell therapy. Continue reading “Organovo Patents Methodology for Producing Kidney Cells from Induced Pluripotent Stem Cells”