Multimaterial and Multiscale Biofabrication of 3D in vitro models of complex tissues – Presented by Giovanni Vozzi, University of Pisa

Giovanni Vozzi

Multimaterial and Multiscale Biofabrication of 3D in vitro models of complex tissues – Presented by Giovanni Vozzi, University of Pisa, at the 3D Medical Conference, which will take place on 30-31 January 2018 at MECC Maastricht, The Netherlands. Read the interview

A biological tissue is a composite material with “bottom-up” hierarchical structure that is closely related to its heterogeneous function. The extracellular matrix modulates biochemical and biophysical signalling, and its rigidity is an important microenvironmental parameter that regulates the spatiotemporal dynamics of intercellular signalling. For this reason, many studies are focused on fabricating scaffolds processed at multiple scales with structural and mechanical properties that are optimal for eliciting specific response or mimic those found naturally. These scaffolds have to present large surface areas that have appropriate topology and biochemical cues (e.g, ligands) at the nanoscale for tissue adhesion, while also exhibiting integral porosity to allow for the exchange of molecules that maintain cellular function.

In this talk, the use of a multiscale and multimaterial process will be presented to develop 3D in vitro model that can mimic the 3D complexity of natural tissue. These novel 3D in vitro models can be used for the study of physio-pathological condition and for the analysis of effects on cell activities of different biomolecule and/or drugs. Continue reading “Multimaterial and Multiscale Biofabrication of 3D in vitro models of complex tissues – Presented by Giovanni Vozzi, University of Pisa”

ETH researchers develop silicone heart that beats almost like a human heart (Video)

silicone heart

ETH researchers from the Functional Materials Laboratory have developed a silicone heart that beats almost like a human heart. In collaboration with colleagues from the Product Development Group Zurich, they have tested how well it works.

It looks like a real heart. And this is the goal of the first entirely soft artificial heart: to mimic its natural model as closely as possible. The silicone heart has been developed by Nicholas Cohrs, a doctoral student in the group led by Wendelin Stark, Professor of Functional Materials Engineering at ETH Zurich. The reasoning why nature should be used as a model is clear. Currently used blood pumps have many disadvantages: their mechanical parts are susceptible to complications while the patient lacks a physiological pulse, which is assumed to have some consequences for the patient. Continue reading “ETH researchers develop silicone heart that beats almost like a human heart (Video)”

First successful printing of cardiac and vascular structures in zero gravity (Video)

A trio of high-tech companies have teamed up to develop a space hardened 3D bioprinter capable of manufacturing human organs and tissues in orbit. A June 14 test of the consortium’s prototype resulted in the first successful printing of cardiac and vascular structures in zero gravity with adult human stem cells. The experiment was performed 30,000 feet over the Gulf of Mexico aboard a Zero Gravity Corporation aircraft capable of repeatedly producing several seconds of sustained microgravity. Continue reading “First successful printing of cardiac and vascular structures in zero gravity (Video)”

Harvard Researchers Reveal New Method for 3D Bioprinting Thick Vascularized Tissue (Video)

A team at the Wyss Institute for Biologically Inspired Engineering at Harvard University and the Harvard John A. Paulson School for Engineering and Applied Sciences (SEAS) has invented a method for 3D bioprinting thick vascularized tissue constructs composed of human stem cells, extracellular matrix, and circulatory channels lined with endothelial blood vessel cells. The resulting network of vasculature contained within these deep tissues enables fluids, nutrients and cell growth factors to be controllably perfused uniformly throughout the tissue. The advance is reported March 7 in the journal Proceedings of the National Academy of Sciences. Continue reading “Harvard Researchers Reveal New Method for 3D Bioprinting Thick Vascularized Tissue (Video)”

MIT’s Biologic program attempts to program living organism and create organically reactive material (Video)

bioLogic is growing living actuators and synthesizing responsive bio-skin in the era where bio is the new interface. We are Imagining a world where actuators and sensors can be grown rather than manufactured, being derived from nature as opposed to engineered in factories. Continue reading “MIT’s Biologic program attempts to program living organism and create organically reactive material (Video)”

‘Bio-3D printer’- based system to create vascular prosthetics (Video)

Small caliber vascular prostheses are not clinically available because synthetic vascular prostheses lack endothelial cells which modulate platelet activation, leukocyte adhesion, thrombosis, and the regulation of vasomotor tone by the production of vasoactive substances. We developed a novel method to create scaffold-free tubular tissue from multicellular spheroids (MCS) using a “Bio-3D printer”-based system. This system enables the creation of pre-designed three-dimensional structures using a computer controlled robotics system. With this system, we created a tubular structure and studied its biological features. Continue reading “‘Bio-3D printer’- based system to create vascular prosthetics (Video)”

The Future of Footwear: 3D Printed Shoes that React to Your Movements (VIDEO)

If you’re familiar with SOLS Systems, you may have thought of them solely as a custom orthotics manufacturer.  If that’s the case, it’s time to expand your schema of what this 3D printing start-up is really about, as SOLS has just unveiled the prototype for a modular, 3D printed robo-boot. Continue reading “The Future of Footwear: 3D Printed Shoes that React to Your Movements (VIDEO)”