As countries worldwide face the challenge of managing the COVID-19 pandemic / Coronavirus, Ultimaker is making its global network of 3D printing hubs, experts, and designers directly available to hospitals in need of tools and applications that are short in supply and can be quickly produced with 3Dprinting.Continue reading “Ultimaker supports the fight against Coronavirus outbreak”
Large-scale tablet production as we know it today was invented in the late 19th century. Although the machinery has, of course, become more modern, the manufacturing process has hardly changed and is still based on the compression of powders and granules.
This traditional tablet manufacturing process is very efficient for large-scale production. Yet, when active pharmaceutical ingredient (API) dosages need to be adapted – as it is the case for clinical studies or for any tablet batch production in smaller volumes – the process is both extremely time-consuming and expensive.
Merck together with EOS is currently developing a GMP-qualified solution that uses additive manufacturing (commonly known as 3D printing) technology combined with powder formulation. Laser sintering technology will simplify tablet production tremendously, leading to significant cost and time savings in clinical development.PRODUCTION OF TABLETS HAS NEVER BEEN SIMPLER, FASTER AND CHEAPER
Tablet manufacturing using additive manufacturing will be as easy as “mixing, printing, done”. The API is mixed with excipients as a powder. A laser then fuses the mixture in a powder bed into tablets layer by layer. The tablets are then coated, and it’s all done!
In addition, 3D printing allows for API formulation to be scalable while avoiding costly reformulations throughout the entire pharmaceutical development and commercial production processes.
This novel approach is being pursued at the Merck Innovation Center, which brings ideas, knowledge and people together to create new viable businesses beyond the company’s current scope. The innovation project can benefit greatly from the long-standing formulation expertise of our Healthcare business sector as well as the experience of our Life Science business with excipients. In addition, we are partnering with EOS, the world’s leading technology supplier in the field of industrial 3D printing of metals and polymers, on this project.
The goal is to establish, in a first step, a Contract Development and Manufacturing Organization offering tablet formulation development and production for clinical trials.
In addition to making tablet manufacturing simpler and reducing time and costs, we envision making it possible to mass produce tablets flexibly and sustainably in line with patient needs. Tablet production could be tailored locally to meet specific market requirements, for example. Or imagine how it could benefit children or elderly people by providing them with tablets in special shapes and colors so that they can easily recognize their medications.
The conference of 3D Medical Printing Conference covers the development of 3D Pharma Printing.
Read more about the Merck / EOS project on the website.
by Carlos Mota, MERLN – Institute for Technology-Inspired Regenerative Medicine
End-stage renal disease (ESRD) affect 10% of the world’s population. Temporary therapies such as dialysis and organ transplantation are deemed insufficient for ESRD patient treatment. Furthermore, due to donor organ shortage multiple patients die while waiting for a suitable organ. Alternative therapies are of outmost importance to circumvent these limitations, but suitable approached to investigate renal disease and regeneration are limited are still largely dependent on animal models. In vitro models with relevant physiologic mimicry and function are necessary for the development of alternative therapies and to unravel new treatment possibilities.Continue reading “Bioprinting of renal models”
Marica Malenica, PhD student, University of Nottingham will demo her project at 3D Medical Conference & Expo
The aim of my project is to develop a platform for continuous production of core-shell particles and to exploit the platform to create polymeric core-shell particles which can be used in selective laser sintering of biomedical products.Continue reading “Jet mixing: towards continuous production of core-shell particles for biomedical selective laser sintering”
Athina Liaskoni, PhD student, University of Nottingham will demo her project at 3D Medical Conference & Expo
Conventional drug delivery systems, tablets, capsules, and solutions, can be limited for the treatment of some diseases. Their necessary frequent administration can be unpleasant to patients and their compliance can be reduced. Sustained release implants can offer a solution and 3D printing a novel method of manufacture of such devices.Continue reading “3D Printed Polymeric Implants For Drug Therapy”
Ling Yong, University of Nottingham will demo her project at 3D Medical Conference & Expo
The main scope of my project is to find novel copolymer that can be 3D printed and can also prevent fungal attachment. The fungal resistant copolymer would potentially be used in medical device application.Continue reading “New fungal resistant copolymer”
Currently there are no retinal tissue engineered grafts for clinical applications. But PhD students at Politecnico di Milano are about to change that. They are working at a project aiming to design functional retinal tissue that could be implanted in patients suffering from age-related macular degeneration.
Currently, the most affordable myoelectric bionic prosthetics cost more than $10,000. But Augment Bionics is going to change that. They are developing software and manufacturing methods that will ultimately reduce production costs and the patient-clinician contact time.Continue reading “Glimpse into the future: 3D printing for breast reconstruction, microrobotics, regenerative medicine, bionic prosthetics & more”
Andrea Alice Konta, Doctoral Researcher, University of Nottingham, will demo her project at 3D Medical Conference & Expo
The aim of the project is to produce new biomaterials in order to expand the library of materials available for two photon polymerisation – a 3D printing technique that allows printing complex structures at the micro and nanoscales – and then use them to manufacture a biomedical device capable of sustained drug release for wet – Age Related Macular Degeneration.Continue reading “New biomaterials”
Yuyang Wu, PhD student | Centre for Additive Manufacturing, AMIChemE , will demo his project at 3D Medical Conference & Expo
Reactive extrusion 3D printing is a process, whereby two feeds are mixed and deposited onto the platform. In-situ reaction bonds the layers through cross-linking. This technology improves the interlayer adhesion, mitigate the thermal distortion and provides faster print speed.Continue reading “Reactive extrusion 3D printing”
About Kety Sindze
I have built up extensive experience in communication & marketing in agencies. However, at 3D ADEPT Media, I have been able grow exponentially and to find something more valuable: authentic values and a common mission: the one to support companies in building the world of tomorrow through innovations. If you are looking for a trade press that is committed to tracking and analyzing the good and the areas for improvement in all sectors related to additive manufacturing, then stay tuned to 3D ADEPT Media.Continue reading “Kety Sindze, 3D ADEPT Media, will moderate at 3D Medical Conference 2020”