BioInks the Lynchpin of 3D Bioprinting: Challenges and Opportunities – Presented by Prasad Shastri, University of Freiburg, at the 3D Medical Conference, which takes place on January 30-31, 2019, at MECC Maastricht, The Netherlands.
Success begets success. This adage is highly relevant for the field of 3D bioprinting today. While the 3D bioprinting as a field has seen explosive growth in the past 5 years, with impressive developments in hardware, the absence of notable translational successes is a clear area of concern. Just as the development of affordable inks drove the adoption of color printers in every household, bioinks are expected to be the lynchpin of 3D bioprinting.
Currently, the bioink segment is largely dominated by methacrylated gelatin (GelMa), alginate and combinations thereof. While these biomaterials are adequate for bioprinting in the laboratory, their translational potential is limited.
For example, structures printed using GelMa require post processing using ultraviolet radiation to ensure mechanical stability, and furthermore, the acrylate chemistry poses both safety and practical limitations in clinical translation. In the case of alginate, the need for a calcium for gelation is problematic as calcium can alter cell fate and status.
Therefore, there is a need to develop bioinks that can provide translational platform and also be easily printed on various print platforms.
This talk will introduce a new family of bioinks that addresses all of the aforementioned issues and provides a clinically translational format to drive 3D bioprinting from the lab to the clinic.
What drives you?
Vexing Scientific questions that impact society
What are the three things you would take with you on a deserted island?
Telescope, Microscope and a giant Lego set
What emerging technologies/trends do you see as having the greatest potential in the short and long run?
Free form biofabrication, nanotechnology, adaptive materials, high resolution imaging, and synthetic biology
What kind of impact do you expect them to have?
Enhance drug screening, drive innovation in regenerative therapies and treatment of cancer
What are the barriers that might stand in the way?
Cost, lack of clear process chain to drive innovation to translational success
Why should the delegate attend your presentation?
Get to know the leading edge of the 3D Bio/Medical Printing field and networking
3D Printing will enable innovation in medicine just like the Gutenberg press opened up access to information
About Prasad Shastri
Prasad Shastri is the Professor of Biofunctional Macromolecular Chemistry and the Director of the Institute for Macromolecular Chemistry at the University of Freiburg.
He is also a core faculty of the DFG funded BIOSS excellence cluster where he holds the position of Professor of Cell Signalling Environments. He received his Ph.D. from Rensselaer Polytechnic Institute (USA) and carried out his post-doctoral work with Prof. Langer at MIT.
He has published over 120 peer-reviewed papers and authored several proceedings, extended abstracts and over 50 issued and pending patents.
His laboratory is active in the area of biomaterials, mechanobiology, intracellular delivery of nanomaterials, cancer biology, functional imaging and in vivo engineering of tissue and made several notable contributions in materials science and biology and pioneered the “in vivo bioreactor” paradigm for de novo engineering bone and cartilage tissue.
About University of Freiburg – Shastri Lab
We are a core group in the Institute for Macromolecular Chemistry (Institut für Makromolekulare Chemie), which is part of the Faculty of Chemistry and Pharmacy at the University of Freiburg. Founded by the Nobel Laureate Prof. Dr. Hermann Staudinger who was awarded the Nobel prize for his “discoveries in the field of macromolecular chemistry”, the Institute for Macromolecular Chemistry (IMC) has and continues to be the place where many of the past and present leaders in polymer science are educated and trained. To recognize the birthplace of polymer science and its unique history the American Chemical Society (ACS) and the Gesellschaft Deutscher Chemiker (GDCh) have designated the IMC as a historic site.
The University of Freiburg is located in Freiburg im Breisgau, a medieval city nestled in the picturesque valley bounded by the Rhine and the black forest in the heart of wine country. The proximity of Freiburg to Switzerland (Basel) and France (Region Alsace) has strongly influenced the city’s culture and ethos. Freiburg is famous for its stunning architecture, church spires, cobblestone streets, street side cafes and restaurants, wineries and a weather that is second to none in Northern Europe. Blessed with more than its share of sunshine, proximity to the snow clad mountaintops of the black forest with awesome ski slopes, and great hiking and biking trails, Freiburg offers something for everyone to indulge in and allows you combine work with fun and recreation. Come and visit us.