Design and characterization of a novel 3D printed pressure-controlled drug delivery system – Presented by Julius Krause, University of Greifswald

Design and characterization of a novel 3D printed pressure-controlled drug delivery system – Presented by Julius Krause, University of Greifswald, at 3D Medical Conference 2019

The aim of the present work was to explore the feasibility of 3D printing via fused deposition modeling (FDM) in the manufacturing of a pressure-controlled drug delivery system.

Eudragit® RS, a brittle polymer with pH-independent solubility, was chosen to be a suitable excipient for the 3D printing of a pressure-sensitive, capsule-like dosage form.

A self-constructed piston extruder was used for hot melt extrusion (HME) of filaments made from Eudragit® RS that could be used for 3D printing.

The effect of physiological pressure events on the drug release behaviour from the novel dosage form was finally tested by using a biorelevant stress test device.

These in vitro experiments demonstrated the rapid and quantitative release of the probe drug after applying realistic pressure events.

This work illustrated that 3D printing can be an interesting technique for the production of pressure-controlled dosage forms as a new concept of oral drug delivery.

About 3D Medical Conference
On January 30-31, 2019, MECC Maastricht, The Netherlands, will host a two-day event focused on 3D Medical Printing.

Focus topics:

  • Medical applications with Virtual Reality / Augmented Reality
  • 3D Bio Printing
  • 3D Dental Printing
  • 3D Medtech Printing
  • 3D Medicine & Pharmaceutics Printing
  • 3D Medical & Dental Scanning
  • 3D Medical & Dental Software
  • 3D Medical (Bio)Materials
  • 3D Medical Workflow & Planning Tools
  • Legal and Regulatory issues regarding 3D Medical printing applications

The audience, a mix of academics, medical professionals, business, technology, regulation and creatives, will get an excellent overview and insight in the medical tech developments from different perspectives.

Combination tickets are available and can be purchased on the conference website.

 

Leave a Reply

Your email address will not be published. Required fields are marked *