Inkjet-printed “Mini-Pills” for preclinical studies

Anastasia Zakharyuta

by Anastasia Zakharyuta, Post-Doctoral Researcher, Boehringer Ingelheim Pharma GMBH Co & KG

This presentation will focus on the development of formulations for pre-clinical studies is attempted in two different forms, namely basic and complex release solid dosage formulations. The former dosage is aimed to provide an alternative to suspensions, as to minimize variability by improving stability and repeatability of the routine formulations.

The latter provides the complex formulations at the early stage of rodent studies, by combining different formulation mechanisms. The different design for such formulations is feasible with regard to the desired release profile and administration route.

Herein, printing procedures are established for solid dosage fabrication, through incorporation of a number of low molecular weight biodegradable polymers via piezo-actuated inkjet printing.

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Inkjet-printed pharmaceutical formulations for preclinical studies – Presented by Anastasia Zakharyuta, Boehringer Ingelheim

Anastasia Zakharyuta

Inkjet-printed pharmaceutical formulations for preclinical studies – Presented by Anastasia Zakharyuta, Boehringer Ingelheim Pharma GMBH Co & KG , at the 3D Medical Conference 5th edition, which will take place on 30-31 January 2018 at MECC Maastricht, The Netherlands.

This presentation will focus on printable formulations for preclinical studies fabricated via piezo-actuated inkjet printing. Herein, incorporation of 2/3 D printing into preclinical formulation routine, as a replacement of techniques, such as homogenization and spray-drying is aimed to enhance quality and repeatability. Further challenges common to drug discovery are addressed via customized formulation design. Results of particulate printing targeting inhalation, intratracheal and oral administration routes, as well as solid oral dosage formulations designed suitable for administration to rodent species will be demonstrated. Continue reading “Inkjet-printed pharmaceutical formulations for preclinical studies – Presented by Anastasia Zakharyuta, Boehringer Ingelheim”