3D-printing of photo-crosslinkable polymers for tissue engineering purposes

Sandra Van Vlierberghe

by Sandra Van Vlierberghe, Professor (BOF-ZAP), Ghent University

Biofabrication is a specific area within the field of tissue engineering which takes advantage of rapid manufacturing (RM) techniques to generate 3D structures which mimic the natural extracellular matrix (ECM). A popular material in this respect is gelatin, as it is a cost-effective collagen derivative, which is the major constituent of the natural ECM. The material is characterized by an upper critical solution temperature making the material soluble at physiological conditions. To tackle this problem, the present work focusses on different gelatin functionalization strategies which enable covalent stabilization of 3D gelatin structures [1, 2].

Continue reading “3D-printing of photo-crosslinkable polymers for tissue engineering purposes”

BioInks the Lynchpin of 3D Bioprinting: Challenges and Opportunities – Presented by Prasad Shastri, University of Freiburg

Prasad Shastri

BioInks the Lynchpin of 3D Bioprinting: Challenges and Opportunities – Presented by Prasad Shastri, University of Freiburg, at the 3D Medical Conference, which takes place on January 30-31, 2019, at MECC Maastricht, The Netherlands.

Success begets success. This adage is highly relevant for the field of 3D bioprinting today. While the 3D bioprinting as a field has seen explosive growth in the past 5 years, with impressive developments in hardware, the absence of notable translational successes is a clear area of concern. Just as the development of affordable inks drove the adoption of color printers in every household, bioinks are expected to be the lynchpin of 3D bioprinting.

Currently, the bioink segment is largely dominated by methacrylated gelatin (GelMa), alginate and combinations thereof. While these biomaterials are adequate for bioprinting in the laboratory, their translational potential is limited. Continue reading “BioInks the Lynchpin of 3D Bioprinting: Challenges and Opportunities – Presented by Prasad Shastri, University of Freiburg”

Multimaterial and Multiscale Biofabrication of 3D in vitro models of complex tissues – Presented by Giovanni Vozzi, University of Pisa

Giovanni Vozzi

Multimaterial and Multiscale Biofabrication of 3D in vitro models of complex tissues – Presented by Giovanni Vozzi, University of Pisa, at the 3D Medical Conference, which will take place on 30-31 January 2018 at MECC Maastricht, The Netherlands. Read the interview

A biological tissue is a composite material with “bottom-up” hierarchical structure that is closely related to its heterogeneous function. The extracellular matrix modulates biochemical and biophysical signalling, and its rigidity is an important microenvironmental parameter that regulates the spatiotemporal dynamics of intercellular signalling. For this reason, many studies are focused on fabricating scaffolds processed at multiple scales with structural and mechanical properties that are optimal for eliciting specific response or mimic those found naturally. These scaffolds have to present large surface areas that have appropriate topology and biochemical cues (e.g, ligands) at the nanoscale for tissue adhesion, while also exhibiting integral porosity to allow for the exchange of molecules that maintain cellular function.

In this talk, the use of a multiscale and multimaterial process will be presented to develop 3D in vitro model that can mimic the 3D complexity of natural tissue. These novel 3D in vitro models can be used for the study of physio-pathological condition and for the analysis of effects on cell activities of different biomolecule and/or drugs. Continue reading “Multimaterial and Multiscale Biofabrication of 3D in vitro models of complex tissues – Presented by Giovanni Vozzi, University of Pisa”

Biofabrication multimaterial & multiscale techniques have greatest potential for developing 3D in vitro model of human tissues or organs – Giovanni Vozzi, University of Pisa

Giovanni Vozzi

Biofabrication multimaterial & multiscale techniques have greatest potential for developing 3D in vitro model of human tissues or organs – Giovanni Vozzi, University of Pisa

Giovanni Vozzi is Associate Professor of Bioengineering at the Department of Ingegneria dell’Informazione of University of Pisa He is member of Directors board of International Society for Biofabrication, of IEEE and Of National Group of Bioengineering. Giovanni Vozzi will speak about Multimaterial and Multiscale Biofabrication of 3D in vitro models of complex tissues at the 3D Medical Printing Conference, Jan 30-31, 2018, at MECC Maastricht.

What drives you?

To show the novel biofabricated techniques developed by my research group. Continue reading “Biofabrication multimaterial & multiscale techniques have greatest potential for developing 3D in vitro model of human tissues or organs – Giovanni Vozzi, University of Pisa”

Is Herston Biofabrication Institute creating the hospital of the future?

Herston Biofabrication Institute

Is Herston Biofabrication Institute creating the hospital of the future? Advances in biofabrication research led by the Herston Biofabrication Institute will transform the way we provide health care by producing innovative personalized and automated treatments.

The Herston Biofabrication Institute is a partnership between Metro North Hospital and Health Service, and QUT.

Launching in 2017, the Herston Biofabrication Institute will advance knowledge and technology in 3D scanning, modelling and printing of bone, cartilage and other human tissue to repair tissue that is lost or damaged. Continue reading “Is Herston Biofabrication Institute creating the hospital of the future?”

New bioprinting technology to be developed by UMC Utrecht, regenHU (VIDEO)

bioprinting

New bioprinting technology to be developed by UMC Utrecht, regenHU. Partnering experts in 3D bioprinting with experts in biomanufacturing has resulted in the first melt electrospinning device that incorporates the use of bio-inks. Housed at the Utrecht Biofabrication Facility, this combination of techniques may lead to improved and more accurate 3D bioprinting for therapeutic use. The Utrecht Biofabrication Facility was established with support of Utrecht University and the UMC Utrecht in 2013. Continue reading “New bioprinting technology to be developed by UMC Utrecht, regenHU (VIDEO)”