An overview of the 4D bioprinting industry and its potential impact on regenerative medicine and human-machine interfaces to diagnose, monitor and treat a wide range of diseases. Novel emerging biofabrication technologies and biomaterials with superior advantages such as nanoscale resolution & cells reaching high viability whilst maintaining metabolic and pluripotent characteristics.Continue reading “The emergence of 4D Bioprinting: Next Generation in regenerative medicine & human-machine interfacing”
Andrea Alice Konta, Doctoral Researcher, University of Nottingham, will demo her project at 3D Medical Conference & Expo
The aim of the project is to produce new biomaterials in order to expand the library of materials available for two photon polymerisation – a 3D printing technique that allows printing complex structures at the micro and nanoscales – and then use them to manufacture a biomedical device capable of sustained drug release for wet – Age Related Macular Degeneration.Continue reading “New biomaterials”
by Liesbet Geris, University of Liege
One of the major challenges in tissue engineering and an essential step towards successful clinical applications is the translation of biological knowledge on complex cell and tissue behavior into predictive and robust engineering processes. Computational modelling can contribute to this, among others because it allows to study the biological complexity in a more quantitative way. Computational tools can help in quantifying and optimizing micro-environmental signals to which cells and tissues are exposed and in understanding and predicting the biological response under different conditions.
A wide variety of model systems has been presented in the context of tissue engineering ranging from empirical models (data-driven) over gene network models to mechanistic models (hypothesis-based), targeting processes at the intracellular over the cellular up to the tissue level. Each model system has its own benefits and limitations which delineate the context in which it can be used. Whereas mechanistic models are used as in silico tools to design new therapeutic strategies and experiments, empirical models are used to identify, in large data sets, those in vitro parameters (biological, biomaterial, environmental) that are critical for the in vivo outcome.Continue reading “Using digital twins to design 3D printed implants for skeletal tissue engineering”
by Sandra Van Vlierberghe, Professor (BOF-ZAP), Ghent University
Biofabrication is a specific area within the field of tissue engineering which takes advantage of rapid manufacturing (RM) techniques to generate 3D structures which mimic the natural extracellular matrix (ECM). A popular material in this respect is gelatin, as it is a cost-effective collagen derivative, which is the major constituent of the natural ECM. The material is characterized by an upper critical solution temperature making the material soluble at physiological conditions. To tackle this problem, the present work focusses on different gelatin functionalization strategies which enable covalent stabilization of 3D gelatin structures [1, 2].Continue reading “3D-printing of photo-crosslinkable polymers for tissue engineering purposes”
Comparing different direct metal printed resorbable medical implants – Presented by Holger Jahr, Univ. Hospital RWTH Aachen, at the 3D Medical Conference, which takes place on January 30-31, 2019, at MECC Maastricht, The Netherlands.
Bone repair biomaterials should possess bone-mimicking fully interconnected porous structures of relevant mechanical properties. Ideally, this is combined with an appropriate biodegradation behavior to enable full regeneration and subsequent biological remodeling. Recent advances in additive manufacturing resulted in biomaterials satisfying the former two requirements, while simultaneously satisfying the latter requirement remains challenging. Continue reading “Comparing different direct metal printed resorbable medical implants – Presented by Holger Jahr, Univ. Hospital RWTH Aachen”
Next generation hydrogels for 3D tissue engineering: From simple bioinks to complex ECM mimics – Presented by Matthew Baker, MERLN Institute
The use of hydrogels as a 3D environment for tissue engineering and as a soft biomaterial scaffold remains one of the most promising and successful material classes, with a long history of development. However, our tool-box for materials remains surprisingly limited, especially when considering the need for customizability. Our lab attacks this problem from two fronts: 1) We use simple, straightforward, and reliable chemical functionalization to create user-friendly “bioinks” for 3D printing of soft tissue constructs, and 2) We create bioinspired hydrogels, based on supramolecular self-assembly, that more closely recapitulate the dynamic nature, structure, and function of the native extracellular matrix (ECM). We ultimately aim to create straightforward and reliable hydrogels, which are robust enough to allow for biofabrication, while being dynamic enough to recapitulate the native cellular environment. Continue reading “Next generation hydrogels for 3D tissue engineering: From simple bioinks to complex ECM mimics – Presented by Matthew Baker, MERLN Institute”
Researchers in AMBER, the Science Foundation Ireland funded materials science centre, hosted in Trinity College Dublin, have created a process to support 3D printing of new bone material. Continue reading “AMBER researchers create 3D bioprinting technology to provide alternatives to bone grafts”
Researchers from the University of Nottingham and the Wyss Institute at Harvard University have developed therapeutic synthetic, light-curable, biomaterials for dental treatments that support native dental stem cells inside teeth to repair and regenerate dentin.
The approach could significantly impact millions of dental patients each year by dental fillings that help heal teeth when they are injured from dental disease or dental surgery. Continue reading “Regenerative dental fillings could help heal your teeth”
As of this month, over 4,000 Americans are on the waiting list to receive a heart transplant. With failing hearts, these patients have no other options; heart tissue, unlike other parts of the body, is unable to heal itself once it is damaged. Fortunately, recent work by a group at Carnegie Mellon could one day lead to a world in which transplants are no longer necessary to repair damaged organs. Continue reading “Carnegie Mellon Researchers Try to Rebuild Hearts Using Biomaterials Printed with Inexpensive Printers (Video)”
At the 3D Bioprinting conference in Maastricht, Optics11 presented their new and revolutionary nanoindentation instrument for (bio)material and tissue characterization. Applications specialist Ernst Breel narrates about this new measurement instrument, the Piuma Nanoindenter. Continue reading “Optics11 at the 3D Bioprinting Conference, introducing the Piuma Nanoindenter”