3D Bioprinting: use of Polycaprolactone in clinical and research biomedical applications

Luca Borro

duo presentation by

Luca Borro, 3D Specialist, 3D Biomedica Advanced Modeling and Printing Technician, Bambino Gesù Children’s Hospital, Rome, Italy

& Andrea Del Fattore, Head of the Bone Physiopathology Group, Bambino Gesù Children’s Hospital, Rome, Italy

Bioprinting is a technology that could revolutionize the biomedical field. It has already been used to engineer constructs that mimic aspects of the anatomical and structural complexity, allowing the production of perfectly functional and “biologically active” patient-specific parts.

One of the most important challenges of bioprinting is the identification of biomaterials that have adequate biocompatibility and biodegradability features to be used in clinical use in humans.

Continue reading “3D Bioprinting: use of Polycaprolactone in clinical and research biomedical applications”

Researchers Create Microneedle Arrays for Transdermal Drug Delivery

Researchers Create Microneedle Arrays for Transdermal Drug Delivery.Drug-loaded microneedle arrays for transdermal delivery of a chemotherapeutic drug were fabricated using multi-material microstereolithography (μSL). These arrays consisted of twenty-five poly(propylene fumarate) (PPF) microneedles, which were precisely orientated on the same polymeric substrate. To control the viscosity and improve the mechanical properties of the PPF, diethyl fumarate (DEF) was mixed with the polymer. Dacarbazine, which is widely used for skin cancer, was uniformly blended into the PPF/DEF solution prior to crosslinking. Each microneedle has a cylindrical base with a height of 700 μm and a conical tip with a height of 300 μm. Continue reading “Researchers Create Microneedle Arrays for Transdermal Drug Delivery”