Creating centimeter-scale complex tissue geometries within seconds via Volumetric Bioprinting

Our finite ability to spontaneously regenerate our organs, associated with increasing longevity, reinforces the need for engineered human tissues. Bioprinting made constructing architecturally complex, centimeter-scale 3D living structures possible in hours, arranging cells and materials into pattern that can hasten maturation into functional tissues. Nevertheless, biological elements such as cells and biomolecules are sensitive to physical stimuli and have shortened lifetime in solution. This can result in the reduction of cell function proportionally to printing time.

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Cellink is partner of the 3D Medical Printing Series

Cellink will exhibit during the 3D Medical Printing Series, and will have a speaker at the 3D Bioprinting Conference on 29 March. CELLINK is creating the future of health as part of BICO, the world’s leading bioconvergence company. At the forefront of the bioprinting industry, CELLINK aims to alleviate organ donor shortage with biofabricated transplantable organs and remains committed to reducing our dependence on animal testing and increasing efficiencies in drug development with more physiologically relevant bioprinted organ models.

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Bioprinting of renal models

carlos mota

by Carlos Mota, MERLN – Institute for Technology-Inspired Regenerative Medicine

End-stage renal disease (ESRD) affect 10% of the world’s population. Temporary therapies such as dialysis and organ transplantation are deemed insufficient for ESRD patient treatment. Furthermore, due to donor organ shortage multiple patients die while waiting for a suitable organ. Alternative therapies are of outmost importance to circumvent these limitations, but suitable approached to investigate renal disease and regeneration are limited are still largely dependent on animal models. In vitro models with relevant physiologic mimicry and function are necessary for the development of alternative therapies and to unravel new treatment possibilities.

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Laser-Assisted Bioprinting: Effect on Bone Regeneration

nathalie dusserre

by Nathalie Dusserre, Research Engineer, ART BioPrint (Inserm U1026, BioTis, Université de Bordeaux, France)

Laser-Assisted Bioprinting (LAB) technology, due to its unprecedented cell printing resolution and precision, is an attractive tool for the in situ printing of a bone substitute. We have previously shown that LAB can be used to induce bone regeneration through the in situ printing of mesenchymal stromal cells, associated with collagen and nano-hydroxyapatite, in a calvaria defect model in mice. In this model, different cell printing geometries proved to impact differently the process of bone tissue regeneration.

program: https://3dmedicalconference.com/program/

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What if every scientist had an easy way to print and pattern cells

Ricky Solorzano

by Ricky Solorzano, CEO, Allevi

In an era where bioprinting continues to hold promise sometimes its hard to understand why and how are they useful. What key applications will allow me to take my research to the next level and stay on the cutting edge. Come and listen to the key ways bioprinting is being most commonly used by researchers around the world.

program: https://3dmedicalconference.com/program/

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In-situ process monitoring during the Selective Laser Melted Ti-6Al-4V porous biomaterials

denis dowling

by Professor Denis Dowling, Director, I-Form Advanced Manufacturing Research Centre, University College Dublin

Selective Laser Melting (SLM) allows for the creation of complex cellular structures, that possess favourable biological properties, these structures are known as porous biomaterials.

This presentation will provide an overview of the printing of cellular Ti-6Al-4V structures, using a production scale SLM system (Renishaw 500M).

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Bioprinting of tissues and organs – Presented by Carlos Mota, Maastricht University

carlos mota

Bioprinting of tissues and organs – Presented by Carlos Mota, Maastricht University, at the 3D Medical Conference, which takes place on January 30-31, 2019, at MECC Maastricht, The Netherlands.

Bioprinting technologies are a group of computer-driven systems used to manufacture three-dimensional (3D) tissue and organ-like constructs. These 3D structures are normally manufactured with bioinks where the combination of specific cells and biomaterials is tuned according to the aimed tissue or organ.

At the MERLN institute, we are using different bioprinting techniques, namely extrusion, droplet-on-demand and microfluidics to develop tissue implants and organ models. Some examples of the tissue implants already developed are constructs for long bone defects and cardiac patch. For the long bone implant, novel alginate-based bioinks have been developed and combined with human periosteum-derived cells. Continue reading “Bioprinting of tissues and organs – Presented by Carlos Mota, Maastricht University”

Bioinspired Heart Valve Prosthesis and Cellular Scaffolds by Silicone 3D Printing – Presented by Fergal Coulter, ETH Zurich – Complex Materials

Fergal Coulter

Bioinspired Heart Valve Prosthesis and Cellular Scaffolds by Silicone 3D Printing – Presented by Fergal Coulter, ETH Zurich – Complex Materials, at the 3D Medical Conference, which takes place on January 30-31, 2019, at MECC Maastricht, The Netherlands.

Artificial heart valves are highly demanded medical devices, but suffer from inferior performance compared to their biological counterparts. To tackle the poor longevity and hemodynamic behavior of many synthetic valves, an additive manufacturing platform was developed that enables the fabrication of polymer heart valves that are customizable to the patient and feature unique biologically-inspired leaflet designs.

Exploiting the shaping freedom of additive manufacturing, the synthetic valves are customized using geometries tailored to fit the anatomy of the patient. The architecture of the leaflet is designed to mimic the fiber reinforcement found in a natural valve. Continue reading “Bioinspired Heart Valve Prosthesis and Cellular Scaffolds by Silicone 3D Printing – Presented by Fergal Coulter, ETH Zurich – Complex Materials”

Announcement by Servier and Poietis of scientific partnership in 4D bioprinting of liver tissues

Servier and Poietis

Announcement by Servier and Poietis of scientific partnership in 4D bioprinting of liver tissues

Paris and Pessac, France – 19 September 2018 – Servier, an independent international pharmaceutical company, and Poietis, a leader in the production of living bioprinted tissues, have announced a scientific partnership to use Poietis’s 4D bioprinting technology for the development and production of liver tissues.

This partnership seeks to improve the detection of drug-induced liver lesions as early as the preclinical trial phase. Such lesions are rare1 but can have serious consequences for patients. This hepatotoxic2 potential is poorly detected by current preclinical models. Beyond animal models, various models based on human cell cultures are available, but most lack longevity and complexity, which limits their usefulness in toxicology. Poietis’s 4D bioprinting technology has emerged as an innovative technology capable of helping to overcome these limitations. Continue reading “Announcement by Servier and Poietis of scientific partnership in 4D bioprinting of liver tissues”