by Carlos Mota, MERLN – Institute for Technology-Inspired Regenerative Medicine
End-stage renal disease (ESRD) affect 10% of the world’s population. Temporary therapies such as dialysis and organ transplantation are deemed insufficient for ESRD patient treatment. Furthermore, due to donor organ shortage multiple patients die while waiting for a suitable organ. Alternative therapies are of outmost importance to circumvent these limitations, but suitable approached to investigate renal disease and regeneration are limited are still largely dependent on animal models. In vitro models with relevant physiologic mimicry and function are necessary for the development of alternative therapies and to unravel new treatment possibilities.
Continue reading “Bioprinting of renal models”
3D-Bioprinting holds much promise in advancing medicine as tool to replicate cellular complexity of tissue environment ex vivo for drug screening and as a means of engineering well-defined functional tissue units for transplantation.
Continue reading “What is the current 3D Bioprinting landscape?”
by Nathalie Dusserre, Research Engineer, ART BioPrint (Inserm U1026, BioTis, Université de Bordeaux, France)
Laser-Assisted Bioprinting (LAB) technology, due to its unprecedented cell printing resolution and precision, is an attractive tool for the in situ printing of a bone substitute. We have previously shown that LAB can be used to induce bone regeneration through the in situ printing of mesenchymal stromal cells, associated with collagen and nano-hydroxyapatite, in a calvaria defect model in mice. In this model, different cell printing geometries proved to impact differently the process of bone tissue regeneration.
Continue reading “Laser-Assisted Bioprinting: Effect on Bone Regeneration”
by Ricky Solorzano, CEO, Allevi
In an era where bioprinting continues to hold promise sometimes its hard to understand why and how are they useful. What key applications will allow me to take my research to the next level and stay on the cutting edge. Come and listen to the key ways bioprinting is being most commonly used by researchers around the world.
Continue reading “What if every scientist had an easy way to print and pattern cells”
by Professor Denis Dowling, Director, I-Form Advanced Manufacturing Research Centre, University College Dublin
Selective Laser Melting (SLM) allows for the creation of complex cellular structures, that possess favourable biological properties, these structures are known as porous biomaterials.
This presentation will provide an overview of the printing of cellular Ti-6Al-4V structures, using a production scale SLM system (Renishaw 500M).
Continue reading “In-situ process monitoring during the Selective Laser Melted Ti-6Al-4V porous biomaterials”
Bioprinting of tissues and organs – Presented by Carlos Mota, Maastricht University, at the 3D Medical Conference, which takes place on January 30-31, 2019, at MECC Maastricht, The Netherlands.
Bioprinting technologies are a group of computer-driven systems used to manufacture three-dimensional (3D) tissue and organ-like constructs. These 3D structures are normally manufactured with bioinks where the combination of specific cells and biomaterials is tuned according to the aimed tissue or organ.
At the MERLN institute, we are using different bioprinting techniques, namely extrusion, droplet-on-demand and microfluidics to develop tissue implants and organ models. Some examples of the tissue implants already developed are constructs for long bone defects and cardiac patch. For the long bone implant, novel alginate-based bioinks have been developed and combined with human periosteum-derived cells. Continue reading “Bioprinting of tissues and organs – Presented by Carlos Mota, Maastricht University”
Bioinspired Heart Valve Prosthesis and Cellular Scaffolds by Silicone 3D Printing – Presented by Fergal Coulter, ETH Zurich – Complex Materials, at the 3D Medical Conference, which takes place on January 30-31, 2019, at MECC Maastricht, The Netherlands.
Artificial heart valves are highly demanded medical devices, but suffer from inferior performance compared to their biological counterparts. To tackle the poor longevity and hemodynamic behavior of many synthetic valves, an additive manufacturing platform was developed that enables the fabrication of polymer heart valves that are customizable to the patient and feature unique biologically-inspired leaflet designs.
Exploiting the shaping freedom of additive manufacturing, the synthetic valves are customized using geometries tailored to fit the anatomy of the patient. The architecture of the leaflet is designed to mimic the fiber reinforcement found in a natural valve. Continue reading “Bioinspired Heart Valve Prosthesis and Cellular Scaffolds by Silicone 3D Printing – Presented by Fergal Coulter, ETH Zurich – Complex Materials”
Announcement by Servier and Poietis of scientific partnership in 4D bioprinting of liver tissues
Paris and Pessac, France – 19 September 2018 – Servier, an independent international pharmaceutical company, and Poietis, a leader in the production of living bioprinted tissues, have announced a scientific partnership to use Poietis’s 4D bioprinting technology for the development and production of liver tissues.
This partnership seeks to improve the detection of drug-induced liver lesions as early as the preclinical trial phase. Such lesions are rare1 but can have serious consequences for patients. This hepatotoxic2 potential is poorly detected by current preclinical models. Beyond animal models, various models based on human cell cultures are available, but most lack longevity and complexity, which limits their usefulness in toxicology. Poietis’s 4D bioprinting technology has emerged as an innovative technology capable of helping to overcome these limitations. Continue reading “Announcement by Servier and Poietis of scientific partnership in 4D bioprinting of liver tissues”
Irish company is undertaking a project to develop 3D bioprinted implants
The Advanced Materials + BioEngineering Research (AMBER) center, headquartered in Dublin, Ireland, is undertaking a project to develop 3D bioprinted implants for people suffering from osteoarthritis. Continue reading “Irish company is undertaking a project to develop 3D bioprinted implants”
Multimaterial and Multiscale Biofabrication of 3D in vitro models of complex tissues – Presented by Giovanni Vozzi, University of Pisa, at the 3D Medical Conference, which will take place on 30-31 January 2018 at MECC Maastricht, The Netherlands. Read the interview
A biological tissue is a composite material with “bottom-up” hierarchical structure that is closely related to its heterogeneous function. The extracellular matrix modulates biochemical and biophysical signalling, and its rigidity is an important microenvironmental parameter that regulates the spatiotemporal dynamics of intercellular signalling. For this reason, many studies are focused on fabricating scaffolds processed at multiple scales with structural and mechanical properties that are optimal for eliciting specific response or mimic those found naturally. These scaffolds have to present large surface areas that have appropriate topology and biochemical cues (e.g, ligands) at the nanoscale for tissue adhesion, while also exhibiting integral porosity to allow for the exchange of molecules that maintain cellular function.
In this talk, the use of a multiscale and multimaterial process will be presented to develop 3D in vitro model that can mimic the 3D complexity of natural tissue. These novel 3D in vitro models can be used for the study of physio-pathological condition and for the analysis of effects on cell activities of different biomolecule and/or drugs. Continue reading “Multimaterial and Multiscale Biofabrication of 3D in vitro models of complex tissues – Presented by Giovanni Vozzi, University of Pisa”