Bioprinting of renal models

carlos mota

by Carlos Mota, MERLN – Institute for Technology-Inspired Regenerative Medicine

End-stage renal disease (ESRD) affect 10% of the world’s population. Temporary therapies such as dialysis and organ transplantation are deemed insufficient for ESRD patient treatment. Furthermore, due to donor organ shortage multiple patients die while waiting for a suitable organ. Alternative therapies are of outmost importance to circumvent these limitations, but suitable approached to investigate renal disease and regeneration are limited are still largely dependent on animal models. In vitro models with relevant physiologic mimicry and function are necessary for the development of alternative therapies and to unravel new treatment possibilities.

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Bioprinting of tissues and organs – Presented by Carlos Mota, Maastricht University

carlos mota

Bioprinting of tissues and organs – Presented by Carlos Mota, Maastricht University, at the 3D Medical Conference, which takes place on January 30-31, 2019, at MECC Maastricht, The Netherlands.

Bioprinting technologies are a group of computer-driven systems used to manufacture three-dimensional (3D) tissue and organ-like constructs. These 3D structures are normally manufactured with bioinks where the combination of specific cells and biomaterials is tuned according to the aimed tissue or organ.

At the MERLN institute, we are using different bioprinting techniques, namely extrusion, droplet-on-demand and microfluidics to develop tissue implants and organ models. Some examples of the tissue implants already developed are constructs for long bone defects and cardiac patch. For the long bone implant, novel alginate-based bioinks have been developed and combined with human periosteum-derived cells. Continue reading “Bioprinting of tissues and organs – Presented by Carlos Mota, Maastricht University”