Next generation hydrogels for 3D tissue engineering: From simple bioinks to complex ECM mimics – Presented by Matthew Baker, MERLN Institute

Matthew Baker

Next generation hydrogels for 3D tissue engineering: From simple bioinks to complex ECM mimics – Presented by Matthew Baker, MERLN Institute

The use of hydrogels as a 3D environment for tissue engineering and as a soft biomaterial scaffold remains one of the most promising and successful material classes, with a long history of development. However, our tool-box for materials remains surprisingly limited, especially when considering the need for customizability. Our lab attacks this problem from two fronts: 1) We use simple, straightforward, and reliable chemical functionalization to create user-friendly “bioinks” for 3D printing of soft tissue constructs, and 2) We create bioinspired hydrogels, based on supramolecular self-assembly, that more closely recapitulate the dynamic nature, structure, and function of the native extracellular matrix (ECM). We ultimately aim to create straightforward and reliable hydrogels, which are robust enough to allow for biofabrication, while being dynamic enough to recapitulate the native cellular environment. Continue reading “Next generation hydrogels for 3D tissue engineering: From simple bioinks to complex ECM mimics – Presented by Matthew Baker, MERLN Institute”

Additive Manufacturing of functionally graded scaffolds for bone tissue engineering – Presented by Ravi Sinha, MERLN Institute, Maastricht University

Ravi Sinha

Additive Manufacturing of functionally graded scaffolds for bone tissue engineering – Presented by Ravi Sinha, MERLN Institute, Maastricht University at the 3D Bioprinting Conference which takes place on Jan 31, 2017 at MECC Maastricht in The Netherlands.

“The classical tissue engineering approach has been to put cells within structural supports (scaffolds) which would resorb or remodel and integrate as the cells grow and form the tissue. Additive manufacturing (AM) has enabled this field immensely, due to the ability of these techniques to produce incredibly complex structures at several size scales, thus trying to mimic complex tissue structures and obtaining functional tissue as a result. Nature, however, does not just use structures, but also gradients in structures as well as mechanical and chemical properties. Continue reading “Additive Manufacturing of functionally graded scaffolds for bone tissue engineering – Presented by Ravi Sinha, MERLN Institute, Maastricht University”