Translational Challenges in 3D-Bioprinting

By Prasad Shastri, Professor of Biofunctional Macromolecular Chemistry & Bioss Professor of Cell Signalling Environments / Director, Institute for Macromolecular Chemistry at University of Freiburg

3D-Bioprinting holds much promise in advancing medicine as tool to replicate cellular complexity of tissue environment ex vivo for drug screening and as a means of engineering well-defined functional tissue units for transplantation. In regards to the latter, 3D-bioprinting offers a critical link between principles of tissue engineering and patient-specific delivery of healthcare.

Continue reading “Translational Challenges in 3D-Bioprinting”

First human corneas have been 3D printed by scientists at Newcastle University (Video)

human corneas

First human corneas have been 3D printed by scientists at Newcastle University

It means the technique could be used in the future to ensure an unlimited supply of corneas. As the outermost layer of the human eye, the cornea has an important role in focusing vision.

Yet there is a significant shortage of corneas available to transplant, with 10 million people worldwide requiring surgery to prevent corneal blindness as a result of diseases such as trachoma, an infectious eye disorder.

In addition, almost 5 million people suffer total blindness due to corneal scarring caused by burns, lacerations, abrasion or disease. Continue reading “First human corneas have been 3D printed by scientists at Newcastle University (Video)”

Partnership for bio-printing of hair, signed by Poietis and L’Oreal

bio-printing

Partnership for bio-printing of hair, signed by Poietis and L’Oreal. L’Oreal has been committed to tissue engineering for almost 30 years and holds unique knowledge and expertise in the field of bio-printing of hair. With this exclusive research partnership, L’Oreal and Poietis are giving themselves the means to pursue a new scientific challenge: bio-printing a hair follicle, the small organ that produces hair, using a bio-printer. Continue reading “Partnership for bio-printing of hair, signed by Poietis and L’Oreal”

First successful printing of cardiac and vascular structures in zero gravity (Video)

A trio of high-tech companies have teamed up to develop a space hardened 3D bioprinter capable of manufacturing human organs and tissues in orbit. A June 14 test of the consortium’s prototype resulted in the first successful printing of cardiac and vascular structures in zero gravity with adult human stem cells. The experiment was performed 30,000 feet over the Gulf of Mexico aboard a Zero Gravity Corporation aircraft capable of repeatedly producing several seconds of sustained microgravity. Continue reading “First successful printing of cardiac and vascular structures in zero gravity (Video)”

Australian Researchers Use Handheld 3D Printing Pen to Draw New Cells Directly onto Bone

In a landmark proof-of-concept experiment, Australian researchers have used a handheld 3D printing pen to ‘draw’ human stem cells in freeform patterns with extremely high survival rates.

The device, developed out of collaboration between ARC Centre of Excellence for Electromaterials Science (ACES) researchers and orthopaedic surgeons at St Vincent’s Hospital, Melbourne, is designed to allow surgeons to sculpt customised cartilage implants during surgery. Continue reading “Australian Researchers Use Handheld 3D Printing Pen to Draw New Cells Directly onto Bone”

Harvard Researchers Reveal New Method for 3D Bioprinting Thick Vascularized Tissue (Video)

A team at the Wyss Institute for Biologically Inspired Engineering at Harvard University and the Harvard John A. Paulson School for Engineering and Applied Sciences (SEAS) has invented a method for 3D bioprinting thick vascularized tissue constructs composed of human stem cells, extracellular matrix, and circulatory channels lined with endothelial blood vessel cells. The resulting network of vasculature contained within these deep tissues enables fluids, nutrients and cell growth factors to be controllably perfused uniformly throughout the tissue. The advance is reported March 7 in the journal Proceedings of the National Academy of Sciences. Continue reading “Harvard Researchers Reveal New Method for 3D Bioprinting Thick Vascularized Tissue (Video)”

Researchers Develop 3D Printing in Gel Technique that Can Be Used in Tissue Engineering (Video)

To improve 3D printing, simply add gel. A fresh technique uses one to support complex shapes that would fall apart under their own weight in normal 3D printing.

This new-found combination of strength and delicacy will be crucial if we’re ever to print the biological structures that make up organs, blood vessels and other tissue.

The gel, which has the consistency of hand sanitiser, is made of an acrylic acid polymer. It works like a scaffold, allowing the printing of intricate patterns that would collapse without its support – such as nested Russian-doll-like structures and thin, complex branching networks. Continue reading “Researchers Develop 3D Printing in Gel Technique that Can Be Used in Tissue Engineering (Video)”