Using digital twins to design 3D printed implants for skeletal tissue engineering

Liesbet Geris

by Liesbet Geris, University of Liege

One of the major challenges in tissue engineering and an essential step towards successful clinical applications is the translation of biological knowledge on complex cell and tissue behavior into predictive and robust engineering processes. Computational modelling can contribute to this, among others because it allows to study the biological complexity in a more quantitative way. Computational tools can help in quantifying and optimizing micro-environmental signals to which cells and tissues are exposed and in understanding and predicting the biological response under different conditions.

A wide variety of model systems has been presented in the context of tissue engineering ranging from empirical models (data-driven) over gene network models to mechanistic models (hypothesis-based), targeting processes at the intracellular over the cellular up to the tissue level. Each model system has its own benefits and limitations which delineate the context in which it can be used. Whereas mechanistic models are used as in silico tools to design new therapeutic strategies and experiments, empirical models are used to identify, in large data sets, those in vitro parameters (biological, biomaterial, environmental) that are critical for the in vivo outcome.

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“Tailored made degradable synthetic polymers for 3D (bio)printing” – Presented by Christian Grandfils, CEIB, University of Liège

Advances in 3D (bio)printing need to have tailored made degradable polymers adapted to build structures mimicking our living structures.

PolyLife, a first spin-off project supported by Wallonia region, and BioMiMedics, an Interreg Meuse-Rhin project, have given us the financial tools to build a reactive extrusion platform allowing to synthesize and process degradable biocompatible polyesters in one single and continuous step. The process is rapid (minute scale), green and the equipment is GMP compliant. Continue reading ““Tailored made degradable synthetic polymers for 3D (bio)printing” – Presented by Christian Grandfils, CEIB, University of Liège”